Personalized Gene Silencing Therapy (SOT/Q-REstrain)

Upper Room Clinic offers SOT infusion therapy—a targeted treatment for chronic Lyme disease, viral infections, and treatment-resistant conditions. This personalized IV therapy uses your own blood to create custom oligonucleotides that may help address persistent health challenges. Available in Toronto and Oakville with Dr. Biljana Kostovic's integrative approach.

What is it?

SOT therapy uses short DNA sequences that target specific pathogens or abnormal cells. It works like a "key and lock" system—custom oligonucleotides bind to genetic sequences in viruses or bacteria, interfering with their replication.

Each treatment is created from your blood sample and tailored to your exact pathogen strain. The oligonucleotides circulate for months, continuously working to address the targeted condition.

RGCC laboratories develop personalized SOT treatments that target Lyme bacteria (Borrelia), persistent viruses like Epstein-Barr or Herpes Simplex, and other chronic infections. The IV infusion delivers these molecules into your bloodstream, reaching tissues throughout your body, including crossing the blood-brain barrier.

What SOT Therapy Can Help You With

Chronic Lyme Disease & Co-Infections

SOT infusion therapy targets Borrelia burgdorferi and co-infections including Bartonella, Babesia, and other tick-borne bacteria. The treatment addresses persistent Lyme symptoms when standard antibiotic protocols haven't provided complete relief or rehabilitation.

Persistent Viral Infections

Chronic viral infections including Epstein-Barr virus (EBV), Herpes Simplex 1 and 2, Cytomegalovirus (CMV), and other persistent viruses respond to targeted SOT therapy. The treatment may help reduce viral load and associated symptoms.

Chronic Health Conditions

SOT therapy supports rehabilitation from various chronic conditions where specific pathogens or cellular dysfunction contribute to ongoing symptoms. The personalized approach addresses your unique health challenges.

Treatment-Resistant Infections

When conventional treatments haven't provided adequate results, SOT infusion therapy offers an alternative approach. The highly specific targeting may address infections that have developed resistance to standard protocols.

The Benefits

SOT infusion therapy offers advantages for patients managing chronic conditions:

  • Custom oligonucleotides precisely target the genetic machinery of cancer cells or chronic pathogens.
  • Provides continuous 24/7 therapeutic action for 3–6 months after a single IV infusion.
  • Crosses the blood-brain barrier—reaching infections or tumours affecting the nervous system.
  • Minimal systemic toxicity as it targets specific genetic sequences without broadly affecting healthy cells.
  • Personalized from your own blood, ensuring treatment aligns with your exact pathogen or tumour profile.
  • Works synergistically with ozone therapy, IV nutrition, and conventional oncology for enhanced outcomes.

Research published in peer-reviewed journals shows promising results, with clinical improvements observed in over 77% of patients receiving therapy.

How Upper Room Clinic Provides SOT Therapy in Toronto & Oakville

  • Chronic Lyme disease and tick-borne co-infections (Bartonella, Babesia)
  • Persistent viral infections (EBV, CMV, HSV-1, HSV-2, HHV-6)
  • Cancer support for solid tumours and haematological malignancies
  • Treatment-resistant chronic infections unresponsive to antibiotics or antivirals
  • Post-treatment cancer surveillance and recurrence prevention• Immune dysregulation driven by chronic pathogen burden

What to Expect

Consultation & Clinical Review
Diagnostic Testing & Pre-Treatment Requirements
Blood Draw for Therapy Creation
Laboratory Production & Wait Time
Treatment Administration
Follow-Up & Ongoing Monitoring
Safety & Monitoring

Your journey begins with a detailed consultation with a trained RGCC practitioner. During this visit, your clinician reviews your medical history, diagnosis, previous treatments, and current goals. They confirm which RGCC therapy (Q-REstrain, Clavic-Q-RE, or Dendritic Cell Therapy) is most appropriate and outline required pre-testing such as Oncotrace, Oncotrail, or serum labs.

Before therapy can be created, specific RGCC diagnostic tests must be completed. These tests identify tumor markers, circulating tumor cells, viral or Lyme signatures, and antigen profiles needed to personalize your treatment. Your team will guide you in completing these tests and submitting any supporting medical documentation.

Once pre-testing is complete, a small blood sample is collected. This sample is shipped to the RGCC laboratory, where scientists isolate your unique genetic markers or immune cells. The personalized therapy is then created based on your individual cancer profile, viral profile, or Lyme-related findings.

Your therapy is produced in a state-of-the-art RGCC laboratory using highly controlled and minimally manipulated processes. Production times typically include: Q-REstrain: ~14 business days Clavic-Q-RE: ~14–21 business days Dendritic Cell Therapy: ~2–4 weeks The clinic will notify you as soon as your personalized therapy arrives and is ready to administer.

Once your therapy is prepared, you return to the clinic for treatment. Q-REstrain: Administered as a personalized autologous preparation. Clavic-Q-RE: Given as three immune-cell infusions, every two weeks over a four-week period. Dendritic Cell Therapy: Delivered as an autologous dendritic cell infusion according to your personalized schedule. Each treatment appointment includes monitoring, education, and supportive care from your clinical team.

After treatment, your practitioner continues to monitor your progress, adjust your integrative plan, and recommend follow-up RGCC testing (such as CTC, Oncometrics, or repeat genetic analysis) to track response and long-term outcomes. Support is available throughout your care to coordinate with your oncologist and other providers as needed.

Upper Room prioritizes safe SOT administration with pre-treatment protocols, infusion monitoring, and post-treatment guidance for managing potential detox reactions. We maintain communication with RGCC laboratories for optimal coordination.

During Treatment

Your SOT therapy plan considers your complete health picture. We evaluate which infections to target first if multiple pathogens are present and coordinate treatment timing with your schedule and other interventions.

Why Choose Upper Room Clinic

Certified RGCC Provider – Part of RGCC's international network, ensuring proper sample handling, laboratory coordination, and appropriate therapy administration.

Functional Medicine Integration – SOT works best within comprehensive care, addressing immune dysfunction, inflammation, nutritional deficiencies, and stress for better outcomes.

Experienced Administration – Dr. Kostovic and our team have extensive experience with IV infusions and complex chronic conditions,s including Lyme disease and persistent viral infections.

Comprehensive Support – Beyond SOT infusion therapy, we offer diagnostic testing, symptom management, nutritional counselling, and rehabilitation support throughout your health journey.

Still have questions?

We would love to hear from you. It’s our pleasure to answer any questions you may have. Drop us a message below!
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Contact Us

Locations
Upper Room Clinic – Oakville
Tel: 647-910-5359
Fax: 289-644-0255
oakville@upperroomclinic.com

Upper Room Clinic – Davisville
Tel: 647-521-8024
Fax: 647-348-8024
hello@upperroomclinic.com

Tuesday to Saturday
11am-6pm

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