IV Ozone uses works with the body’s innate healing mechanisms to support optimal (re)balance and functioning. When applied directly to the blood it works as a light switch: it turns on your immune system, which your red blood cells break down sugars. As a wellness tool, there is no comparison. It slightly increases the concentration of hydrogen peroxide in the blood or area injected. The small increase in hydrogen peroxide disappears quickly and is replaced with copious amounts of antioxidants, cell-protecting proteins, feel-good neurotransmitters and immunomodulating messengers.
IV Ozone 10 Pass enhances our bodies’ innate ability to heal by activating the immune system. There are a variety of indications such as:


IV Ozone works at the root level of your biology — activating your body's own healing intelligence to produce benefits that ripple across every system.
Our lead physician, Dr. Biljana Kostovic, is a leader in Ozone Therapy in Canada. She uses the highest-end IV ozone delivery system, the Zotzmann 2000, to ensure optimal ozone delivery into the blood. She has been accredited with global leadership groups and trained alongside pioneers in the field including Dr. Frank Schallenberger, Dr. Robert Rowen, and ACAM.
A former department head in Charlotte County, New Brunswick, Dr. Kostovic brings institutional leadership and clinical excellence in equal measure. With specialties in Emergency Medicine and Pain Medicine she brings a rare combination of rapid-response When you sit in that chair, you're surrounded by a team that has been trained by one of the most clinically prepared physicians in the field.
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During a 10 Pass session, a small amount of your blood — approximately 250ml per pass — is drawn out through an IV into a sterile, vacuum-sealed bottle. Ozone and oxygen are then infused into that blood at a precise concentration (70 gamma), and the ozonated blood is returned to your body through the same IV site. This cycle is repeated 10 times, meaning by the end of your session, approximately 2 to 2.5 litres of your blood has been ozonated and re-oxygenated. The whole process typically takes between 45 minutes and 90 minutes, depending on your hydration levels and how long you've been receiving ozone therapy.
IV Ozone has a broad range of clinical applications because it works at the level of your blood, immune system, and cellular energy production. People come to us for ozone therapy to support chronic infections and viral load, immune dysfunction, chronic pain, fatigue and low energy, metabolic conditions, gastrointestinal repair, adrenal dysfunction, anti-aging and vitality optimization, and recovery from chronic illness. It has also been shown to improve lung capacity, reduce oxidative stress, regulate blood sugar metabolism, and support tissue and organ repair. Many patients also use it as a proactive wellness and longevity tool.
Think of ozone as a master switch for your body's healing systems. When introduced into the blood, ozone reacts with the plasma to produce a small, controlled amount of hydrogen peroxide — a signalling molecule that activates a cascade of immune and cellular responses. This triggers the Nrf2 gene pathway, which ramps up your body's own antioxidant production, including glutathione, superoxide dismutase, and catalase. Ozone also stimulates mitochondrial biogenesis — essentially encouraging your cells to produce more energy — and increases the production of 2,3-DPG, a molecule that helps your red blood cells release more oxygen into oxygen-deprived tissues. The result is a body that is better oxygenated, better defended, and better equipped to heal itself.
IV Ozone Therapy has an excellent safety profile and serious adverse reactions are very rare. Some patients experience mild, transient effects during the session itself — such as light-headedness, a sense of chest fullness, relaxation, or even a brief feeling of euphoria — all of which typically resolve quickly. After your session, some people experience what is called a Herxheimer reaction: a temporary flu-like response (body aches, fatigue, headache, mild fever) that occurs as harmful microorganisms die off and your body clears the debris. This is actually a sign the therapy is working. The IV site may also be mildly red, swollen, or bruised, and because we use heparin (a blood thinner) during the procedure, there may be some minor prolonged bleeding at the site for several hours after treatment. Our team monitors you throughout your session and will walk you through everything to expect before you leave.
Most people are excellent candidates for IV Ozone Therapy, particularly if you are dealing with chronic illness, compromised immunity, chronic pain, fatigue, metabolic dysfunction, gastrointestinal issues, or adrenal dysfunction — or if you are simply an athlete or health-conscious individual looking to optimize your performance and longevity. However, IV Ozone is not recommended if you have a blood clotting disorder such as thrombocytopenia or hemophilia, a G6PD deficiency, a known allergy or dietary restriction related to pork (as we use heparin, a pork-derived blood thinner), or veins that are very small or difficult to access. If you're unsure whether this therapy is right for you, our team will review your health history before your first session.
Preparation makes a meaningful difference in how smoothly your session goes. Before your appointment, drink at least 1 to 2 litres of water — hydration increases the size of your veins and reduces the viscosity of your blood, making the passes faster and more comfortable. Eat a light meal 1 to 2 hours beforehand as well. After your session, keep drinking plenty of water to help your body flush out the toxins that ozone will help mobilize. For at least 48 hours following treatment, avoid smoking, alcohol, and recreational drugs, and steer clear of NSAIDs like ibuprofen, as these can interfere with the immunomodulatory effects of the therapy. Avoid strenuous exercise for the rest of the day, keep your IV site covered for at least 6 hours, and avoid scheduling your session within 2 days of any planned surgery.
The number of sessions needed varies depending on your health goals and current condition. Some patients feel a significant difference after just one or two sessions, while those dealing with chronic illness or infection typically benefit from a series of treatments spaced over several weeks. Your provider will recommend a personalized protocol based on your intake assessment and how your body responds. Many patients who begin with a therapeutic series continue with periodic maintenance sessions to sustain the benefits over time.
IV Ozone 10 Pass Therapy was originally developed in Germany by Dr. Johann Lahodny, who pioneered the hyperbaric method and created the Zotzmann Ozon 2000 — the gold standard ozone generator used worldwide. At The Upper Room Clinic, we use the Zotzmann 2000, the same machine Dr. Lahodny developed and continues to teach with today. This matters because not all ozone equipment is created equal — the Zotzmann 2000 delivers ozone at a precise, consistent concentration using a secure, safety-locked hyperbaric system, ensuring that every pass is administered at the therapeutic 70 gamma concentration your body needs. Our lead physician, Dr. Kostovic, has completed training with Dr. Lahodny as well as other global leaders in ozone medicine including Dr. Robert Rowen and Dr. Frank Schallenberger — so you can be confident the therapy is being delivered exactly as it was designed.

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Locations
Upper Room Clinic – Oakville
Tel: 647-910-5359
Fax: 289-644-0255
oakville@upperroomclinic.com
Upper Room Clinic – Davisville
Tel: 647-521-8024
Fax: 647-348-8024
hello@upperroomclinic.com
Tuesday to Saturday
11am-6pm
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