Chronic Fatigue & Low Energy

Persistent fatigue is one of the most common reasons patients book with Upper Room Clinic in Toronto. Whether it shows up as morning exhaustion, post-exertional crash, brain fog, or a slow burnout that won't resolve with rest, low energy is a symptom — not a diagnosis. Our integrative approach is to look upstream, find the root cause, and build a personalized plan around testing, targeted therapies, and lifestyle support.

If you've been told your bloodwork is “normal” but you still feel exhausted, you are not alone — and there's almost always more to investigate.

Why fatigue is more than “feeling tired”

Persistent low energy that lasts more than six months and isn't improved by rest can indicate dysfunction across multiple systems: mitochondrial energy production, hormone balance, thyroid function, gut and microbiome health, nutrient deficiencies, chronic infection, sleep architecture, or unaddressed chronic stress and trauma. Standard primary-care workups are designed to rule out the most common diagnoses (anemia, hypothyroidism, depression, sleep apnea) and often stop there. Integrative medicine looks deeper — at the systems that conventional bloodwork doesn't routinely measure.

Common root causes we investigate

Mitochondrial dysfunction — the cellular machinery that produces ATP may be underperforming, damaged by chronic stress, infection, toxic load, oxidative stress, certain medications, or aging
Hormonal imbalance — thyroid (including subclinical hypothyroidism, Hashimoto's, reverse-T3-dominant patterns), adrenal/cortisol, perimenopause/menopause, and andropause shifts
Nutrient deficiencies — B12, vitamin D, iron, ferritin, magnesium, CoQ10, carnitine, and other cofactors of energy metabolism
Chronic infection or post-viral syndrome — post-COVID fatigue, EBV reactivation, chronic Lyme, mold-related illness
Sleep disorders — sleep apnea (often underdiagnosed in women), circadian disruption, insomnia, non-restorative sleep architecture
Gut and microbiome dysfunction — nutrient malabsorption, dysbiosis, food sensitivities, leaky gut, chronic gut inflammation
Toxic burden — heavy metals, environmental toxins, mold biotoxins, long-term low-grade exposure
Chronic stress and HPA axis dysfunction — sustained stress depletes regulation of cortisol, adrenaline, and downstream hormones
Inflammation and oxidative stress — chronic low-grade inflammation underlies most of the patterns above

In many patients, fatigue is the result of two or more of these working together. Effective care addresses the constellation, not a single cause.

The Benefits

Treatment plans are personalized — there is no single “fatigue protocol” — but most plans draw from these therapies:

NAD+ IV therapy for mitochondrial energy support and cellular repair
High-dose nutrient infusions to correct documented deficiencies efficiently when oral repletion is too slow
Hormone optimization — thyroid, adrenal, and sex-hormone support based on testing
Mitochondria Renew Program — our structured multi-month protocol combining diagnostics and IV therapy
HOCATT ozone sauna and detoxification to reduce toxic burden
Custom IV infusions built around your specific testing results
Health coaching for sleep, circadian alignment, nutrition, movement, and stress regulation
Referrals and coordination with sleep medicine, psychiatry, or other specialists when indicated

Who we see

Patients with chronic fatigue syndrome (ME/CFS), long COVID, post-infection fatigue, perimenopause and andropause-related fatigue, athletes seeking recovery, busy professionals managing burnout, and parents trying to function on broken sleep with everything else stacked on top.

We do not promise miracle outcomes. We do build careful, evidence-informed plans that move the dial for most patients over weeks to months, with consistent care.

No items found.

What to expect

No items found.

During Treatment

The initial consultation typically lasts 60–90 minutes and includes a thorough history, review of any prior workups, and discussion of your goals. Diagnostic phase usually takes 2–4 weeks depending on which tests we run. After test results return, you receive a written treatment plan with a timeline and expected milestones. Most patients begin to notice changes in sleep, baseline energy, or symptom severity within 4–12 weeks of consistent care. Chronic, complex cases often require 3–6 months for meaningful change and may benefit from longer arcs and maintenance care.

How we approach fatigue care

Most patients begin with an integrative consultation that reviews medical history, prior workups, current symptoms, and lifestyle factors. From there we recommend a tailored testing plan, which may include:

Functional medicine bloodwork — comprehensive thyroid panel including reverse T3 and antibodies, full hormone panel, fasting insulin, inflammation markers, full nutrient panel
Mitochondrial markers — organic acids (urine), CoQ10, carnitine, B-vitamin status
Gut and microbiome testing — comprehensive stool analysis where indicated
Heavy metal and toxin panels — when exposure history or symptom pattern suggests
Sleep evaluation — referral or at-home sleep study where indicated
Advanced infection panels — EBV, CMV, Lyme, mold biomarkers as indicated by history

After testing, we present findings and a written treatment plan with realistic timeline expectations. We work alongside any specialist team you already have and add the integrative layer that conventional care often doesn't include.

Locations
Upper Room Clinic – Oakville
Tel: 647-910-5359
Fax: 289-644-0255
oakville@upperroomclinic.com

Upper Room Clinic – Davisville
Tel: 647-521-8024
Fax: 647-348-8024
hello@upperroomclinic.com

Tuesday to Saturday
11am-6pm

Quick Links

Services Programs locations PRICING ABOUT US

Stay connected

Thank you! Your submission has been received!

Oops! Something went wrong while submitting the form.