Clavic-Q-RE is an autologous adoptive cellular therapy developed by RGCC.
Using a small blood sample, RGCC isolates five types of immune cells — macrophages, natural killer cells, dendritic cells, cytotoxic T-lymphocytes, and antibody-producing plasma cells. These cells are then expanded and primed in the laboratory with peptides designed to target your specific tumour before being infused back into your body over three carefully timed doses.
This approach falls under the category of Autologous Multi-lineage Adoptive Cell Therapy — a form of personalized immunotherapy that harnesses both the innate and adaptive branches of your immune system rather than relying on a single cell type.
Your provider may recommend Clavic-Q-RE if you:
Clavic-Q-RE is not recommended for CNS (brain) cancers, children under 18, those with active autoimmune disease, pregnancy or breastfeeding, recent blood transfusions (within 120 days), or active infections or high inflammation.

Clavic-Q-RE is an emerging and investigational therapy developed by RGCC, a research organization with laboratories in Greece and Germany. The therapy has been classified as a Cell Therapy Medicinal Product (CTMP) by the European Medicines Agency (EMA) and clinical trials are underway.
While early results and preliminary research are encouraging, showing upregulation of immunity and activation of key immune markers, this therapy is not standard of care and results will vary between individuals. We are committed to transparency about what we know and what is still being studied.
We offer Clavic-Q-RE as part of a thoughtful, integrative approach to cancer care, and we will always discuss the full picture with you including the evidence, the unknowns, and whether this therapy is appropriate for your specific situation.
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From your initial blood draw to the completion of your third dose, the active treatment phase spans approximately 7–8 weeks. Including mandatory follow-up testing, the full monitored period extends to approximately 7 months (Day 210). This follow-up is an essential part of the therapy — it allows us and RGCC to evaluate your immune response and determine whether a booster round is needed.
It is strongly recommended to schedule all three doses in advance before receiving your first infusion. If an unexpected delay arises, the therapy can be administered up to one week late without significant loss of efficacy. Beyond that window, the potency of the cells may be reduced. Your provider will work with you to reschedule as quickly as possible if delays occur.
Clavic-Q-RE works best when your system is free of cytotoxic therapies. You will need to pause chemotherapy, radiation, high-dose Vitamin C IVs, and certain other immune-suppressing treatments before and during the therapy window. Your provider will review your full treatment plan and guide you on what needs to be held and for how long. After your final dose, you will need to remain off cytotoxic and immune-suppressing therapies for 120 days to allow the therapy to build lasting immune memory.
Because Clavic-Q-RE is made entirely from your own cells, the risk of immune rejection or serious adverse reactions is very low. Most patients tolerate the therapy well. Possible side effects are generally mild and may include flu-like symptoms (low-grade fever, chills, fatigue), injection site reactions or skin rash, and temporary inflammation near the tumour site. There have been no reported severe anaphylactic reactions associated with this therapy, though as with any medical treatment, rare reactions are always possible. Our team monitors you closely throughout each infusion.
Clavic-Q-RE is an investigational therapy that has been classified as a Cell Therapy Medicinal Product (CTMP) by the European Medicines Agency (EMA), and clinical trials are currently underway. Preliminary research has shown promising results, including upregulation of key immune markers (CD80, CD86, CD28) and activation of both innate and adaptive immunity. As with all emerging therapies, results vary between individuals.
Most side effects, if they occur, appear within 72 hours of each infusion and are mild — a low-grade fever, fatigue, or temporary flu-like symptoms are the most commonly reported. These are often considered a sign that your immune system is responding. You should contact our clinic if your fever rises above 102°F (39°C), if you develop hives or a rash, or if you experience significant swelling or discomfort near the tumour site. We will provide you with clear after-care instructions before you leave each appointment.
Clavic-Q-RE can theoretically be used for any solid tumour or blood cancer where circulating tumour cells (CTCs) are detectable in the blood. It is not suitable for CNS (brain) cancers due to the blood-brain barrier. The baseline Oncotrace test, completed before therapy begins, helps confirm whether your cancer meets the eligibility criteria and whether your immune system is in a position to respond well.
The therapy package is $17,475 CAD and includes all three doses of Clavic-Q-RE, two follow-up Immune Frame tests, and two follow-up Oncotrace tests at Day 120 and Day 210. Please note that the baseline Immune Frame ($1,800 CAD) and baseline Oncotrace ($1,800 CAD) required before therapy begins are not included in the package price. A blood draw fee of $75 CAD is charged per visit. Blood draws are available on Tuesdays only. Full payment is required on the day of your blood draw. Because your therapy is produced personally for you, it cannot be refunded once production has begun at the RGCC lab.

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