Prolotherapy & Prolozone

Knee, back, shoulder or neck pain that keeps coming back? Prolotherapy and Prolozone® injections restart your body's own tissue repair — non-surgical, steroid-free, physician-performed in Toronto and Oakville.

How Does It Work?

Recurring pain usually means the connective tissue itself — ligaments and tendons that healed loose, weak or incompletely after an injury. Painkillers mask that. They don't repair it.

Prolotherapy and Prolozone® take the opposite approach. A precise injection of dextrose, local anaesthetic and — in Prolozone — medical ozone gas restarts your body's own healing response inside the damaged tissue. For most patients that means less pain, better stability, and joints that hold up because the tissue is stronger, not because the nerves are numbed.

The technique was developed by Dr. Frank Shallenberger, founder of the American Academy of Ozone Therapy, and is delivered at Upper Room Clinic by physicians trained in regenerative injection therapy.

What it costs

Prolozone — neck, back, jaw or prostate: $350 per site
Prolozone — all other sites: $270 per site
Additional site treated in the same session: $100
Most treatment plans: 3–6 sessions, spaced 1–2 weeks apart

Full details on our Services & Diagnostic Testing Price List. No referral needed.

The Benefits

1. Reduces pain quickly: Ozone calms inflammation and improves circulation, often giving noticeable relief within days.

2. Stimulates tissue repair and regeneration: Prolozone activates collagen-producing cells, helping joints, ligaments, and tendons rebuild naturally.

3. Strengthens and stabilizes joints: By healing and tightening weakened connective tissue, it improves joint stability and reduces recurring injuries.

4. Improves oxygenation and blood flow: Ozone enhances oxygen delivery to damaged areas, speeding up healing where blood supply is normally poor.

5. Supports arthritis and degenerative conditions: Effective for osteoarthritis in the knees, hips, shoulders, spine, and small joints, helping preserve function and mobility.

6. Helps chronic or hard-to-heal injuries: Ideal for long-standing pain or injuries that haven't responded to other treatments, offering a non-surgical path to recovery.

Is Prolotherapy or Prolozone Right For You?

These injections work best when pain comes from weakened ligaments, tendons or joint structures. Patients most commonly see us for:

Neck and Back pain
Neck instability
Acute injuries- sports
Rotator cuff injuries
Degenerative and arthritic joints, big and small.
Fascial pain, including plantar fasciitis
Carpal Tunnel Syndrome
TMJ pain
Sciatica
Tendonitis, such as Tennis Elbow
Neuromas
Pelvic & Groin Pain
Chronic Post-Surgical Pain
Non-Healing Fractures
Painful Scars
Enlarged Prostate

Soccer player taking a shot on goal — sports injuries treated with prolozone injections

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What to Expect

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During Treatment

A Prolozone® session typically lasts 15–25 minutes. You may feel a brief sense of pressure, fullness, or warmth during the ozone injection. Mild soreness for 24–48 hours is common as the healing response is activated. Most patients can resume normal activities immediately, though strenuous exercise should be avoided for the first day. Depending on the chronicity and severity of the condition, most patients require 3–6 sessions, spaced 1–2 weeks apart. Long-standing or severe injuries may require additional treatments or combined regenerative approaches.

Why Choose Upper Room Clinic

The Upper Room Clinic is one of the leading providers of Prolozone® therapy in Toronto and Oakville, offering precise, physician-delivered injections that target pain at its source. Our doctors are highly trained in regenerative medicine and create personalized treatment plans based on each patient's unique injury and biomechanics. We specialize in chronic and hard-to-treat pain, helping patients who haven't improved with standard therapies finally achieve meaningful relief. With convenient locations in midtown Toronto and Oakville, we provide compassionate, evidence-informed care that supports true healing and long-term recovery.

Serving Toronto & Across Ontario

We proudly serve patients throughout Toronto and Ontario, including North York, Scarborough, Markham, Etobicoke, Mississauga, and Brampton.